Ongoing research in Dr. Maury's laboratory focuses on the interactions between enveloped viruses and host cells. Recent studies have examined specific interactions between viral glycoproteins and cellular receptors, and also the cellular endocytic pathways that are instrumental for virus uptake. These studies have investigated glycoproteins from several viruses - including filoviruses and alphaviruses - that have broad cellular tropisms. Dr. Maury's group is currently exploring the abilities of these viral glycoproteins to mediate virus particle uptake into airway human cells. Dr. Maury is a new Associate Member in the Center and brings considerable basic virology expertise to gene therapy application with retroviruses and lentiviruses. She is currently applying her research to the pseudotyping of feline immunodeficiency virus-based vectors to enhance their efficiency for gene delivery to the airway.
Selected Publications:
Brindley, M.A., and Maury, W. 2008. Equine infectious anemia virus entry occurs through clathrin-mediated endocytosis. J Virol 82:1628-1637.
Brindley, M.A., and Maury, W. 2005. Endocytosis and a low-pH step are required for productive entry of equine infectious anemia virus. J Virol 79:14482-14488.
Sinn, P.L., Goreham-Voss, J.D., Arias, A.C., Hickey, M.A., Maury, W., Chikkanna-Gowda, C.P., and McCray, P.B., Jr. 2007. Enhanced gene expression conferred by stepwise modification of a nonprimate lentiviral vector. Hum Gene Ther 18:1244-1252.
Brindley, M.A., Hughes, L., Ruiz, A., McCray, P.B., Jr., Sanchez, A., Sanders, D.A., and Maury, W. 2007. Ebola virus glycoprotein 1: identification of residues important for binding and postbinding events. J Virol 81:7702-7709.
