Mark Chapleau, Ph.D. (Full Member)
Professor, Dept. of Internal Medicine, University of Iowa
Professor, Dept of Molecular Physiology & Bi, University of Iowa

http://www.int-med.uiowa.edu/Divisions/Cardiology/Directory/MarkChapleau.html

Research Interest    

Dr. Chapleau's research program focuses on neural mechanisms of cardiovascular regulation, with emphasis on the baroreceptor reflex and control of sympathetic nerve activity. Ongoing studies are investigating: mechanisms of baroreceptor mechanotransduction; the roles of autocrine/paracrine factors and K+ channels in the modulation of membrane excitability in baroreceptor and sympathetic neurons; and mechanisms of abnormal autonomic regulation during aging and in pathological states including hypertension, hypercholesterolemia, and heart failure. Experimental approaches include integrative studies in genetically modified mice, viral vector-based gene transfer, and electrophysiologic and imaging studies of isolated neurons in culture. Gene transfer applications include: 1) the topical administration, in vivo, of adenoviral and lentiviral vectors to carotid sinus adventitia and sympathetic ganglia of rabbits and mice, in order to modulate baroreceptor and sympathetic nerve activity; and 2) gene transfer in vitro to isolated neurons, in order to identify the cellular and molecular mechanisms in which the factor of interest is involved. Examples of transgenes studied include superoxide dismutase, catalase, nitric oxide synthase, and methionine sulfoxide reductase.

Selected Publications:

Ma, X., Zhang, H.J., Whiteis, C.A., Tian, X., Davisson, R.L., Kregel, K.C., Abboud, F.M., and Chapleau, M.W. 2006. NAD(P)H Oxidase-induced Oxidative Stress in Sympathetic Ganglia of Apolipoprotein E Deficient Mice. Auton Neurosci 126-127:285-291.
Ma, X., Bielefeldt, K., Tan, Z.Y., Whiteis, C.A., Snitsarev, V., Abboud, F.M., and Chapleau, M.W. 2006. Dual Mechanisms of Angiotensin-induced Activation of Mouse Sympathetic Neurones. J. Physiol. 573.1: 45-63.

Snitsarev, V., Whiteis, C.A., Chapleau, M.W., and Abboud, F.M. 2007. Mechano- and Chemo-Sensitivity of Rat Nodose Neurones- Selective Excitatory Effects of Prostacyclin. J. Physiol., 582.1: 177-194.

Gu, H., Lin, M., Liu, J., Gozal, D., Scrogin, K.E., Wurster, R., Chapleau, M.W., Ma, X., and Cheng, Z. 2007. Selective Impairment of Central Mediation of Baroreflex in Anesthetized Young Adult Fischer 344 Rats after Chronic Intermittent Hypoxia. Am. J. Physiol. Heart Circ. Physiol., 293: H2809-H2818.

Tan, Z.-Y., Lu, Y., Whiteis, C.A., Benson, C.J., Chapleau, M.W., and Abboud, F.M. 2007. Acid-sensing Ion Channels (ASICs) Contribute to Transduction of Extracellular Acidosis in Rat Carotid Body Glomus Cells. Circ. Res., 101: 1009-1019.

Roghair, R.D., Segar, J.L., Volk, K.A., Chapleau, M.W., Dallas, L.M., Sorenson, A.R., Scholz, T.D., and Lamb, F.S. 2009. Nitric Oxide and Vascular Superoxide Anion Contribute to Sex-Specific Programmed Cardiovascular Physiology in Mice. Am. J. Physiol. Integr. Comp. Regul. Physiol., 296: R651-R662.

Publications from PubMed