Mark Anderson, MD, PhD (Full Member)
Potter-Lambert Chair in Cardiology, University of Iowa

http://www.int-med.uiowa.edu/Divisions/Cardiology/Directory/MarkAnderson.html

Research Interest    

The Anderson laboratory focuses on signaling by the multifunctional Ca2+ and calmodulin-dependent protein kinase II (CaMKII) in the heart. CaMKII overactivity can cause heart failure and arrhythmias, and has recently emerged as a validated therapeutic target for heart disease. CaMKII binds, phosphorylates, and regulates ion channels, Ca2+ homeostatic proteins, transcription factors and cell survival proteins. Dr. Anderson's group is using viral technologies to specifically knock down and replace CaMKII and downstream CaMKII targets as an approach toward more clearly delineating these CaMKII-mediated signaling pathways that are crucial to heart function.

Selected Publications:

Rong Zhang, Michelle SC Khoo, Yuejin Wu, Igor Dzhura, Gemin Ni, Tatiana A Vishnivetskaya, Chad Grueter, Ernest C Madu, Vsevolod V Gurevich, Roger J Colbran, Mark E Anderson. Calmodulin kinase II inhibition protects against structural heart disease. Nature Med. 2005, 11:409-417. Published with an accompanying editorial.

Rong Zhang, Igor Dzhura, Chad Grueter, William Thiel, Roger J Colbran, Mark E Anderson. A dynamic alpha-beta inter-subunit agonist signaling complex is a novel feedback mechanism for regulating L-type Ca2+ channel opening. FASEB J. 19:1573-1575, 2005.

Michelle SC Khoo, Rong Zhang, Gemin Ni, Chad Grueter, Yingbo Yang, Wei Zhang, Lisa Mendes, Eric N Olson, Roger J Colbran, Mark E Anderson. Death, cardiac dysfunction and arrhythmias due to up-regulation of calmodulin kinase II in calcineurin-induced cardiomyopathy. Circulation, 114:1352-9, 2006.

Erickson JR, Joiner MA, Guan X, Kutschke W, Yang J, Oddis CV, Bartlett RK, Lowe JS, O?Donnell S, Aykin-Burns N, Zimmerman MC, Zimmerman K, Ham AL, Weiss RM, Spitz DR, Shea MA, Colbran RJ, Mohler PJ, Anderson ME. A dynamic pathway for calcium independent activation of CaMKII by methionine oxidation. Cell. 2008 (In press).

Publications from PubMed