Kevin Rice, Ph.D. (Full Member)
Professor of Pharmaceutics, University of Iowa
Division Head, Medicinal/Natural Products Chem., University of Iowa

http://www.pharmacy.uiowa.edu/mnpcphar/Pages/rice.htm

Research Interest    

Research in Dr. Rice's laboratory focuses on the development of non-viral targeted gene delivery. The main emphasis is on designing low molecular weight glycopeptide and polyethylene glycol peptide carrier molecules that, when combined with plasmid DNA, spontaneously form colloidal particles. When dosed intravenously, these particles target mammalian lectins on the hepatocyte or Kupffer cell surface and, once internalized into these cells, mediate transient gene expression. The primary goal of research in the Rice laboratory is to design carrier molecules capable of controlling the level and duration of gene expression, with the aim of applying this knowledge toward a variety of therapeutic interventions. More recently, his group has applied these carriers to delivery of siRNA and shRNA expression cassettes in vivo and used biophotonic imaging to assess the levels of knockdown efficiency of the various delivery systems.

Selected Publications:

Huang, Y.C., Rice K.G., Mooney, D.J. Long-term In Vivo Gene Expression Via Delivery of PEI-DNA Condensates from Porous Polymer Scaffolds. Human Gene Therapy (2005) 16, 609-617.

Huang, Y.C., Rice, K.G., Mooney, D.J. Bone Regeneration in a Rat Cranial Defect with Delivery of PEI-Condensed Plasmid DNA Encoding for Bone Morphogenetic Protein-4. Gene Therapy (2005) 12, 418-426.

Rettig G. R., McAnuff M., Liu D, Kim J.S. and Rice, K.G. Quantitative Bioluminescence Imaging of Transgene Expression In Vivo Anal. Biochem. (2006) 335, 90-94.

McAnuff M., Rettig G. R. and Rice, K.G. Potency of siRNA Versus shRNA Mediated Knockdown in Vivo (2007) J. Pharm. Sci., 96, 2922-2930.

Publications from Gene Therapy Center

Publications from PubMed