Kevin Campbell, Ph.D. (Full Member)
Professor, University of Iowa
Investigator, Howard Hughes Medical Institute
Professor, University of Iowa
Roy J. Carver Chair, University of Iowa

http://www.physiology.uiowa.edu/campbell/index.htm

Research Interest    

Research in Dr. Campbell's laboratory is focused on two main topics: 1) the dystrophin-glycoprotein complex and 2) the pathogenesis of muscular dystrophy and therapeutic strategies for its treatment. Alterations in the dystrophin-glycoprotein complex cause several forms of muscular dystrophy, including those involving abnormal central nervous system development and function. The laboratory is investigating the structure and function of the dystrophin-glycoprotein complex in skeletal, cardiac, and smooth muscle, as well as in non-muscle tissues including the brain and peripheral nervous system. With regard to this complex, we are particularly interested in better understanding: 1) the post-translational processing of dystroglycan as required for its functional activity, and steps in this process that are targeted in muscular dystrophy; 2) the functional roles of members of the sarcoglycan-sarcospan complex; and 3) the role of dystroglycan within the central and peripheral nervous systems, with respect to processes including neuronal migration, peripheral nerve conduction, and synaptic plasticity. Muscular dystrophy research in Dr. Campbell's laboratory utilizes a variety of biochemical and genetic tools including human patient samples, spontaneous mutant or gene-targeted mice, viral gene transfer and stem cell therapy. The group's approaches are geared to understanding disease mechanisms and forming the basis of therapeutic studies in vivo. The group has also uncovered a muscle membrane repair pathway that is responsible for at least two forms of muscular dystrophy that are not associated with the dystrophin-glycoprotein complex.

Selected Publications:

Bansal, D., Miyake, K., Vogel, S.S., Groh, S., Chen, C-C., Williamson, R., McNeil, P.L., Campbell, K.P. Defective Membrane Repair in Dysferlin-Deficient Muscular Dystrophy. Nature 423(6936):168-172, 2003.

Sampaolesi, M., Torrente, Y., Innocenzi, A., Tonlorenzi, R., D?Antona, G., Pellegrino, M.A., Barresi, R., Bresolin, N., Cusella de Angelis, M.G., Campbell, K.P., Bottinelli, R. and Cossu, G. Cell Therapy of Alpha-Sarcoglycan Null Dystrophic Mice Through Intra-arterial Delivery of Mesoangioblasts. Science 301(5632): 487-492, 2003.

Barresi, R., Michele, D.E., Kanagawa, M., Harper, H.A., Dovico, S.A., Satz, J.S., Moore, S.A., Zhang, W., Schachter, H., Dumanski, J.P., Cohn, R.D., Nishino, I. and Campbell, K.P. LARGE Can Functionally Bypass á-Dystroglycan Glycosylation Defects in Distinct Congenital Muscular Dystrophies. Nat Med 10(7): 696-703, 2004.

Kanagawa, M., Saito, F., Kunz, S., Yoshida-Moriguchi, T., Barresi, R., Kobayashi, Y.M., Muschler, J., Dumanski, J.P., Michele, D.E., Oldstone, M.B.A. and Campbell, K.P. Molecular Recognition by LARGE is Essential for Expression of Functional Dystroglycan. Cell 117(7): 953-964, 2004.

Han, R., Bansal, D., Miyake, K., Muniz, V.P., Weiss, R.M., McNeil, P.L., Campbell, K.P. Dysferlin-Mediated Membrane Repair Protects the Heart From Stress-Induced Left Ventricular Injury. J Clin Invest 117(7):1805-1813, 2007.

Publications from PubMed