Joseph Dillon, M.D. (Full Member)
Assistant Professor of Medicine, University of Iowa

http://www.int-med.uiowa.edu/Divisions/Endocrine/Directory/JosephDillon.html

Research Interest    

Dr. Dillon's research uses rat models to investigate: 1) signal transduction mechanisms used by the pancreatic beta cell, and 2) the genetic basis of type 2 diabetes. Type 2 diabetes is a disorder with a strong genetic component. Although some forms of this diesase are related to autosomal-dominant, inherited single-gene mutations, the more common variants are multigenic in origin. With the long-term goal of using gene therapy to treat this disorder, current endeavors include: 1) the genetic manipulation of insulin-secreting cells to give these cells the ability to secrete insulin in a glucose-regulated manner, with the aim of using such cells in transplantation experiments; and 2) the testing of novel viral vectors for their ability to target gene expression to the pancreatic islet.

Selected Publications:

Dillon J.S., Lu, M., Bowen, S., Boyd, AE. The recombinant rat glucagon-like peptide-1 receptor expressed in an a-cell line (INR1-G9) is coupled to adenylyl cyclase activation and intracellular calcium release. Experimental & Clinical Endocrinology & Diabetes. 113(3):182-189, 2005.

Liu, D., Ren, M., Dillon J.S. Dehydroepiandrosterone inhibits agonist-induced intracellular calcium release in INS-1 cells by a non-genomic mechanism. Steroids. 71:691, V699, 2006.

Fang X, Dillon J.S., Hu, S., Harmon, S.D., Yao, J., Falck, J.R., Spector A.A. 20-carboxy arachidonic acid is a dual activator of peroxisome proliferator activated receptors alpha and gamma. Prostaglandins and Other Lipid Mediators. 82:175-184, 2007.

Liu, D., Iruthayanathan, M., Homan, L.L., Wang, Y., Yang, L., and Dillon, J.S. Dehydroepiandrosterone stimulates endothelial proliferation and angiogenesis through extracellular signal-regulated kinase 1/2-Mediated Mechanisms. Endocrinology 149:889-898, 2008.

Publications from Gene Therapy Center

Publications from PubMed