Joel Kline, M.D. (Full Member)
Professor, Director UI Asthma Center, University of Iowa

http://www.int-med.uiowa.edu/Divisions/Pulmonary/Directory/JoelKline.html

Research Interest    

Dr. Kline's research focus is the study of asthma and airway inflammation, which his laboratory studies in both humans and animal models. The Kline group is particularly interested in interactions between toll-like receptors (TLR) and innate immune responses that have relevance to lung inflammation, and he has pioneered studies on immune effects of CpG DNA (a TLR-9 agonist) in the lung. Indeed, Dr. Kline was the first to demonstrate that responses engendered by CpG motifs may function both preventively and therapeutically in murine models of airway disease. This work is directly relevant to gene therapy since the common non-viral vectors (and some viral vectors) contain substantial numbers of CpG motifs that may contribute to inflammation when administered to the airway.

Selected Publications:

Kitagaki, K., Businga, T.R., and Kline, J.N. 2006. Oral administration of CpG-ODNs suppresses antigen-induced asthma in mice. Clin Exp Immunol 143:249-259.

Kitagaki, K., Businga, T.R., Racila, D., Elliott, D.E., Weinstock, J.V., and Kline, J.N. 2006. Intestinal helminths protect in a murine model of asthma. J Immunol 177:1628-1635.

Kline, J.N. 2007. Immunotherapy of asthma using CpG oligodeoxynucleotides. Immunol Res 39:279-286.

Jain, V.V., and Kline, J.N. 2004. CpG DNA: immunomodulation and remodelling of the asthmatic airway. Expert Opin Biol Ther 4:1533-1540.

Publications from Gene Therapy Center

Publications from PubMed